How The web Fax Delivering Improvements Your Home business

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Geneticist's 'personalized medicine' study focuses on himself

Self-experimentation is a venerable tradition in science.

London surgeon John Hunter deliberately gave himself gonorrhea (and inadvertently, syphilis) in 1767 ? and suffered from effects of the diseases in his old age.

Jonas Salk dosed himself with his new polio vaccine in 1952 before testing it on anyone else. Down the years, scientists have inhaled poisonous gases, swallowed possible treatments for worms and detonated bombs at close range to assess the effects on their own bodies.

Now Michael Snyder has joined their ranks.

The geneticist didn't risk life and limb, but he did sacrifice his privacy ? inviting colleagues to sequence his DNA and track tens of thousands of markers in his blood over a period of 14 months, when he was sick and when he was well, ultimately crunching billions of measurements on the molecular details of his body.

Some of the results came as big, and not very welcome, surprises, uncovering, among other things, that he was at risk for Type 2 diabetes, and capturing the precise moments when the disease took hold in his body.

Snyder, who heads the genetics department at Stanford University's medical school, says the work is more than just a curiosity. He thinks that his experiment, published Thursday in the journal Cell, offers a taste of what medicine may be like someday for everyone.

Physicians talk often about "personalized medicine": the idea that therapies should be tailored to each patient's unique genetic and medical profile. Doctors already practice a sort of personalized medicine when they "type" a tumor to find the most effective chemotherapy drug. Someday, scientists like Snyder say, it will be a routine part of prevention too.

But if the gantlet his team ran is any indication, that day isn't upon us yet.

First, the researchers sequenced Snyder's genome ? the 6 billion letters of his DNA blueprint ? several times over, to assess his risk for various conditions. (And they sequenced Snyder's mother's genome as well, to learn which genes he got from each parent.) They drew Snyder's blood regularly to see how proteins, RNA and a swath of other chemicals in his body increased or decreased when he was in good health and bad ? his "omics" profile. They monitored his immune system and other health measures.

"Your genome shows what you're predisposed for. Your 'omics' profile tells you what's really going on," Snyder said. "This is a whole new level."

In all, Snyder said, the team crunched 3 billion measurements gathered over 20 time points, tracking close to 40,000 variables. The typical blood panel a patient gets at the doctor's office looks at about 20 variables.

Snyder's DNA didn't look terribly concerning, he said, though the team did find gene variants associated with basal cell carcinoma, high cholesterol and high triglycerides. One mutation he shares with his 83-year-old mother has been linked to a blood cell disorder called aplastic anemia, but neither has developed symptoms. He was more alarmed to learn he had versions of genes that put him at risk for Type 2 diabetes, which doesn't run in his family.

Snyder asked his colleagues to monitor his blood sugar closely. Intriguingly, his levels shot up about two weeks after he suffered a respiratory infection. The "omics" analysis showed that his body's ability to regulate glucose faltered during his illness, and he was ultimately diagnosed with diabetes.

It was the first time anyone had made a connection between viral infection and the onset of that disease, Snyder said.

He believes that if he hadn't performed this experiment on himself it would have been months or years before he would have discovered his diabetes ? perhaps time enough for complications of the disease to set in.

"If you find things early you can manage them," he said. "But if you find them late, it can be too late."

Luckily for him, simple measures such as improving his diet and losing some weight returned his blood sugar to normal.

He now plans to do similar profiles of 250 pre-diabetic patients to more rigorously observe what happens during the onset of diabetes.

Harvard geneticist George Church, who was not involved in the research, said Snyder's experience doesn't prove the infection-Type 2 diabetes link, but he says it's "potentially exciting" for future investigation.

Snyder, meanwhile, imagines a day when everybody will have their genomes sequenced and will be able to monitor their "omics" at home to manage their health, in a sort of smaller-scale version of his own experiment.

But before that can happen, teams like his will need to catalog the genomes, proteins, RNA and other chemicals of thousands of people along with their health information ? and then build a database describing how genes and changes in physiology relate to traits and disease.

The price of the process will have to come down, too. Even without factoring in man-hours and analysis, it cost thousands of dollars each of the 20 times the team pored over Snyder's blood results.

eryn.brown@latimes.com

Source: http://feeds.latimes.com/~r/latimes/news/science/~3/BYDxBPeITC4/la-sci-personalized-medicine-20120317,0,7748318.story

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Learning Information about 401k Investing | Business and Finance ...

The purpose of 401k investing is to save for your retirement. This is a type of retirement plan that your employer may provide. Before you invest in this type of plan you need to meet all the requirements that have been set by your employer. Savings for the plan come from contributions out of your earnings.

Research the type of investing strategies that are offered with your savings plan. This will allow you to create a portfolio for your investing needs. When eligible to invest you will typically be given a list of available options that are available to invest your money. You will need to choose the option that meets your retirement needs. The investment option chosen will dictate how your investments will grow over time.

Retirement plans provided by employers will require various investment strategies. You have multiple factors to consider when developing any type of strategy. Factors to consider age, other type of options that are used for investment assets and an individual?s tolerance to risk. The amount of risk applied to a retirement plan will cause the value of a portfolio to grow or even lose value. This is based on how you diversify your investment portfolio.

Check the performance of your retirement plan annually or semi-annually. Make sure that investments you have selected are meeting your required performance targets. If your investment is not adequately meeting target goals, you may need to reassess your asset allocation criteria. This is typically required of you at the beginning of each year, by your employer. Refer to the information that is provided from your employer for any specifics.

The administrator or your retirement plan performs the record keeping, reporting and transactions done with respect to the selections you have made for your plan. However, the primary decision to re-balance or reallocate your investment assets is up to you. The annual summary for your plan?s performance will be provided to you each year. A benefit statement is also provided to you from your employer every 12 months.

When you change jobs or plan to retire your retirement plan may be able to be transferred. This process is known as a rollover. If a new employer will accept the transfer of assets from an existing plan, then a continuation of your investment strategy is available. However, not all employers accept transfers. This means that you must transfer your assets into an individual retirement account.

Withdrawals from an IRA do not need to be made until you reach the age of 70 and one-half. You can use this type of retirement account for planning out your financial needs. This will need to be done early so you can save enough money for retirement.

The requirements for 401k investing mean that you typically must attain the age of 59 and one-half before you can withdraw funds without suffering a penalty. If you are below this age and plan to retire, the account will need to be transferred to an IRA. This can be done by contacting a financial adviser that will manage the funds in your account.

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Source: http://www.franequity.com/learning-information-about-401k-investing/

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Treasure Coast Real Estate | OCEAN DUNES Homes For Sale ...

by starfish on March 16, 2012

Find OCEAN DUNES Homes For Sale and OCEAN DUNES Home Values. We also have information on mortgages, insurance, movers and other Treasure Coast Real Estate Services for anyone looking to sell or buy a home in beautiful Saint Lucie COUNTY Florida.

Paul Kitchen and Starfish Team provide clients, family and close friends with professional, honest and dependable service. A resident of Treasure Coast, Paul is extremely familiar with the local neighborhoods including OCEAN DUNES, school districts and the Treasure Coast Real Estate market in this beautiful Florida town.

Paul Kitchen
Broker-Owner
Starfish Real Estate
8985 SE Bridge Road Hobe Sound, Florida 33455
(772) 539-8380
(800) 793-7304 toll free
Treasure Coast Real Estate
Treasure Coast Real Estate Blog

Tagged as: OCEAN DUNES, Treasure Coast Real Estate

Source: http://www.treasure-coast-living.com/2012/03/16/treasure-coast-real-estate-ocean-dunes-homes-for-sale-march-2012/

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Video: Adrien Brody on new film, Gillette commercial?

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