Monday, April 29, 2013

Militants try to shape Pakistani election with bombs

The wave of political violence has killed at least 60 people in recent weeks, and many of the attacks have been directed at candidates from secular parties opposed to the Taliban.

By Hussain Afzal,?Associated Press / April 28, 2013

Taliban bombs targeting politicians in northwestern?Pakistan?on Sunday killed 11 people, the latest in a series of attacks meant to disrupt next month's parliamentary election, police said.

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The wave of political violence has killed at least 60 people in recent weeks, and many of the attacks have been directed at candidates from secular parties opposed to the Taliban. That has raised concern the violence could benefit hard-line Islamic candidates and others who are more sympathetic to the Taliban because they are able to campaign more freely without fear of being of being attacked.

Pakistani Taliban spokesman Ahsanullah Ahsan claimed responsibility for the three attacks, plus two others against secular parties in the southern port city of Karachi on Saturday that killed four people and wounded over 40.

"We are against all politicians who are going to become part of any secular, democratic government," Ahsan told The Associated Press by telephone from an undisclosed location.

The first bomb on Sunday ripped through the campaign office of Syed Noor Akbar on the outskirts of Kohat city, killing six people and wounding 10, police officer Mujtaba Hussain said.

A second bomb targeted the office of another candidate, Nasir Khan Afridi, in the suburbs of Peshawar city. That attack killed three people and wounded 12, police officer Saifur Rehman said.

The politicians were not in their offices at the time of the blasts. They are both running as independent candidates for parliament to represent constituencies in?Pakistan's?rugged tribal region along the Afghan border, the main sanctuary for Taliban and Al Qaeda militants in the country.

Many politicians running in the May 11 election from the tribal region have their offices located elsewhere and find it hard to campaign in their constituencies because of the danger. The two who were attacked Sunday are considered to hold relatively progressive views compared to the deeply conservative Islamic beliefs of many in the tribal region.

The third attack occurred in the town of Swabi, where a bomb went off during a small rally held by the Awami National Party, which has been repeatedly targeted by the Taliban. The blast killed two people and wounded five, said police officer Farooq Khan. The two candidates targeted in the attack, Ameer Rehman and Haji Rehman, were not hurt.

The Pakistani Taliban have been waging a bloody insurgency against the government for years that has killed thousands of civilians and security personnel. The group's goal is to oust?Pakistan's?democratic government and implement a system based on Islamic law.

In mid-March, the Taliban threatened attacks against three secular parties that have earned the militants' ire by supporting military operations against them in the northwest: the Awami National Party, the Muttahida Quami Movement, and the?Pakistan?People's Party. The Taliban have carried out at least 20 attacks against politicians and campaign workers since then, mostly from these three parties.

The violence has forced the parties to close dozens of campaign offices and has prevented them from holding large political rallies that are normally the hallmark of Pakistani elections. Many of the candidates have had to find ways to campaign from a distance, relying more on social media, advertisements and even short documentaries to rally support.

That has put these candidates at a disadvantage, and many have complained the militant violence amounts to vote rigging.

Candidates from Islamic parties and others who have advocated negotiating peace with the militants rather than fighting them have been able to campaign with much less fear of being attacked.

Former Prime Minister Nawaz Sharif, head of the?Pakistan?Muslim League-N party, held a rally with several thousand people in the northern town of Murree on Sunday without incident. Many analysts predict Sharif's party will come out on top in the parliamentary election.

The Taliban issued a statement earlier this year requesting that Sharif and the heads of the country's two largest Islamic parties mediate peace negotiations. Sharif declined but said he was a supporter of the talks.

The parties that have been targeted by the Taliban also support peace negotiations with the militants, but only if they lay down their weapons and accept the constitution first ??conditions the militant group has rejected.

* Associated Press Writers Riaz Khan and Rasool Dawar in Peshawar contributed to this report.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/Eiv4LiaKRtI/Militants-try-to-shape-Pakistani-election-with-bombs

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Authorities investigating if Boston suspect had training



>>> we turn to the boston bombing investigation. now new questions tonight about the bapath the suspects may have taken leading up to that violent and deadly day two weeks ago tomorrow. nbc 's michelle franzen is in boston now with the very latest. michelle, good evening.

>> reporter: good evening, lester. nbc news has confirmed that russian authorities in the initial days after the bombing here in boston reached out to u.s. authorities and told them back in 2011 that russian authorities had had actually had a wiretapped conversation that they had recorded between tamerlan tsarnaev and his mother and a conversation where the russians say they justed jihad. this conversation, authorities tell us, say there is no link or connection at this time to the bombings here in boston but investigators are still tracking leads here and overseas. a key focus for investigators centers on tamerlan 's tsarnaev's visit to dagestan in 2012 and what he did during his six-month stay. authorities tell nbc news they are weighing russian reports on what they learned about tamerlan while he he was visiting family. big question sunday for lawmakers, whether tamerlan received training during his trip.

>> i suspect that ultimately we're going to conclude that a lot of the radicalization took place before the trip, that these brothers particularly the older brother, were more self-radicalized, online sources were among the most significant factors.

>> reporter: several former counterterrorism officials tell nbc news investigators are leaning toward a theory that the two suspects did not have training and acted alone. pointing to serious flaws in the operation. the suspect had no escape plan and returned home after the bombing. police say they car jacked a vehicle and stole money from the victim. and on the day of the bombing, authorities say they stood out an, unlike everyone else, were not in a panic. in boston this morning, at the old south church , a moving walk and vigil to the marathon finish line. healing moments for young and old alike, and signs the boston strong spirit is thriving. and all along boylston street only one business is now not open. the rest of them have opened here and the memorial back here, there is much more than just an outpouring of people and written notes. we're also learning that the one fund created to help victims has received nearly $27 million in donations. lester?

>> michelle franzen tonight, thank you.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b47a839/l/0Lvideo0Bmsnbc0Bmsn0N0Cid0C51695750A/story01.htm

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Minneapolis council member drops DFL endorsement bid (Star Tribune)

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Sunday, April 28, 2013

Obama to nominate Anthony Foxx as transportation secretary (reuters)

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Overseer of U.S. victim funds says work wrenching

BOSTON (AP) ? Massachusetts lawyer Kenneth Feinberg has been near the heart of some of the worst catastrophes, dealing with people who've faced profound loss after 9/1l, the BP oil spill, the Virginia Tech shootings, and the Colorado movie theater ambush.

Now, he's adding the Boston Marathon bombings to his workload, managing a victims' compensation fund as he did after the previous tragedies.

The 67-year-old Feinberg said his work takes an emotional toll but is about wanting to help, in the same spirit as those who donate.

The experiences are wrenching, he said. And recipients invariably resent him, thinking he's trying to put a price on the priceless things they've lost.

"Don't expect thanks or appreciation or gratitude, none of that," Feinberg said. "We have very emotional victims and you're offering them money instead of a limb, instead of the return of a family member. This is a no-win situation."

But he keeps saying yes to the work because he wants to help.

"Look at the amount of money that pours in from private people, private citizens?" he said. "How do you say no if the governor calls, the mayor?"

In 1984, the Brockton native was appointed to distribute money from a $180 million settlement for military veterans exposed to Agent Orange. His work was stellar enough to prompt a call when President George W. Bush was looking for someone to manage the 9/11 Victims Compensation Fund. Since then, the calls have come regularly.

Currently, he is advising a panel distributing money after the December school massacre in Newtown, Conn., and mediating settlement discussions between Penn State and alleged sex abuse victims of former football coach Jerry Sandusky.

The One Fund ? now nearing $26 million ? was established to help victims of the April 15 marathon explosions that killed three people and injured more than 260. Feinberg has established an aggressive timeline in Boston. He hopes to meet with families by June 15 and get checks out by June 30.

Most of the work is pro bono, including the Boston Marathon job, though Feinberg was paid for his work with the 9/11 fund and the BP oil spill, the job that earned Feinberg the most abuse.

In his 2012 book, "Who Gets What," he said he became a "human pinata." Residents complained about the speed and distribution of the payouts, and insults flew at public meetings. "You are such a lying piece of (garbage)," one person said.

Meanwhile, lawyers scoffed at his vigorous declarations of independence from BP, a claim Feinberg said now widely believed.

Attorney Anthony Tarricone, now of the Boston firm Kreindler & Kreindler, who represented both BP and 9/11 victims, called Feinberg the perfect person to manage the marathon fund. Tarricone cited Feinberg's legal skills and the respectful, kind manner in which he dealt with 9/11 families.

"He was fair, he listened to the families, the families felt as if they were being listened to, and that he was understanding what they were going through," Tarricone said.

Former U.S. Attorney General John Ashcroft, who worked with Feinberg when he was handling the 9/11 fund, said Feinberg balances compassion for the victims with vigilance in protecting the money from abuse.

"I can't say exactly how he handles it emotionally and psychologically, I just know that he does it professionally," Ashcroft said. "I don't think the world would keep going back, knocking on his door, saying 'Ken, we need you again,' if they were displeased because there's nothing that locks him into this responsibility."

The eventual total of the One Fund will determine who can be helped. Payment for deaths takes priority, followed by compensation for physical injuries. Payment for mental health issues comes if money is available, Feinberg said.

His principle is to pay the same amount on all deaths. His top indicator for determining the seriousness of the injuries is the length of the hospital stay.

Feinberg has established an aggressive timeline. He hopes to meet with families by June 15 and get checks out by June 30. Along the way, the classical music aficionado will most likely take refuge in music when he can.

"During the day, I'm working on a project that shows you how uncivilized some people can be and how they willy-nilly, at random, kill and maim people," he said. "And at night you turn on Mozart, and it's the height of civilization." It reminds him "that mankind isn't all bad."

Source: http://news.yahoo.com/overseer-us-victim-funds-says-wrenching-070532658.html

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Saturday, April 27, 2013

Shrink-Wrapped Space Shuttle Atlantis Uncovered for Display

CAPE CANAVERAL, Fla. ??How do you un-shrink-wrap a space shuttle?

As workers at the Kennedy Space Center Visitor Complex learned Thursday (April 25), very slowly and very carefully.

NASA's retired space shuttle Atlantis, which since November has been covered in 16,000 square feet (1,486 square meters) of white plastic, was partially revealed Thursday at the Florida spaceport's visitor center. The planned day-long process to unwrap the orbiter stretched into two ? work picked up again Friday morning ? and required cherry pickers, vacuum cleaners, box cutters and patience.

"This is the very first step in unveiling Atlantis," said Tim Macy, director of project development and construction for Delaware North Parks and Resorts, which runs the Kennedy Space Center Visitor Complex for NASA. "She has been in a plastic 16-millimeter-thick cocoon."

Unlike a caterpillar's cocoon, the shuttle's wrap was intended to shield it from the metamorphosis occurring outside, rather than in. Atlantis rolled into its new $100 million exhibition facility while the five-story building was still under construction.

"It was for her own protection," Macy explained. "With all the construction dust and overspray and everything else that is happening here, it kept her protected in a nice shrink-wrapped sealed environment."

Construction workers used knives to score the plastic cover, being careful not to knick the spacecraft in the process, before carefully cutting away and lifting the wrap off the vehicle. Even before they made the first slice, the workers vacuumed segments of the plastic to avoid any dust falling onto Atlantis. [Gallery: Revealing Atlantis: Space Shuttle Un-Shrink Wrapped]

"This is a priceless artifact," Macy told collectSPACE.com. "She has had a pretty rough life, she's had 33 missions in space and has gone over 12 million miles. It is incumbent upon us to take care of it."

"I would hate to think that maybe if we drop some plastic on it, it might scrape it or catch on it or do something. That wasn't going to be the case," he said.

Macy said unwrapping Atlantis was easier than wrapping it, but emphasized that all of this was unprecedented.

"It is the first time anything like this has ever been done," he said. "You see it on some other airplanes and some other aircraft but it is the first time a shuttle has been wrapped. It is the first time a shuttle has been unwrapped. It is the first time a shuttle has been in this configuration. So it is not like we have a lot of practice on it."

"We're going to take it real slow," Macy said. "What we find in construction is that the slower you go, the faster you go, because you are not making mistakes."

After a brief delay to finish painting one of the exhibit's walls, work got underway to unwrap Atlantis at 9 a.m. EDT (1300 GMT) Thursday. About six hours later, the shuttle's nose and crew compartment, its vertical stabilizer (tail) and aft engines, as well as one wing were uncovered ? though the left wing's reveal was partially the work of gravity as the wrap slipped towards the floor.

In addition to displaying Atlantis 30 feet (9 meters) off the ground, the exhibit also presents the shuttle tilted 43.21 degrees to one side, an angle that previously only astronauts could see when the orbiter was in space. Set to open to the public on June 29, the "Space Shuttle Atlantis" attractionis designed to provide visitors the chance to see the orbiter up-close and like never before.

Almost as soon as Atlantis is fully unwrapped, work will begin to open the space shuttle's 60-foot-long (18 meter) payload bay doors, which Macy said is the final big hurdle before the exhibit's public debut.

"Those payload bay doors aren't meant to be opened in one-g [gravity]," Macy said. "Normally they open up in space, no big deal. Here, you really have to pay attention to them. It is a long door ? they're not very heavy and flimsy isn't really the right word, but they are very delicate."

See shuttles.collectspace.com for continuing coverage of the delivery and display of NASA's retired space shuttles.

Follow collectSPACE.com on Facebook and on Twitter at @collectSPACE. Copyright 2013 collectSPACE.com. All rights reserved.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/shrink-wrapped-space-shuttle-atlantis-uncovered-display-165926740.html

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Friday, April 26, 2013

Time Warner Cable revenue rises 7 percent

By Mark Elkington MADRID, April 24 (Reuters) - Even Lionel Messi, so often Barcelona's saviour, was at a loss to explain how the La Liga leaders could come back from their Champions League semi-final mauling in Munich. Barca were thumped 4-0 away by an impressive Bayern Munich in their first leg on Tuesday, putting in one of their most toothless displays in recent memory. On Wednesday, they were greeted with newspaper headlines such as 'Historic beating' in Madrid-based daily Marca, 'Catastrophe' in Barcelona-based Mundo Deportivo, and 'Azulgrana Waterloo' in daily El Mundo. ...

Source: http://news.yahoo.com/time-warner-cable-revenue-rises-7-percent-101021326--finance.html

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Wall Street rises on earnings, drop in jobless claims

By Caroline Valetkevitch

NEW YORK (Reuters) - Stocks rose on Thursday, boosted by gains in shares of materials companies, including iron ore producer Cliffs Natural Resources Inc , and by a drop in weekly jobless claims.

Cliffs jumped 20.6 percent to $21.97 after it posted earnings late on Wednesday that were much better than analysts had estimated. The S&P 500 materials index <.splrcma> was up 1.4 percent.

Telecommuncations companies also rose following gains in Verizon Communications Inc . The stock rose 2.1 percent to $52.87 after sources told Reuters it has hired advisers to prepare a possible $100 billion cash and stock bid to take full control of Verizon Wireless from joint venture partner, Vodafone Group Plc .

Companies reporting results in the past 24 hours lifted the growth forecast for S&P 500 companies quarterly earnings to 3.6 percent. At the start of the reporting period the forecast was growth of just 1.5 percent.

Investors have closely watched earnings to see if they would be enough to extend the market's uptrend that began at the start of the year, especially since recent economic data has suggested slowing growth in March and early April. Worries about global weakness have also hung over the market.

"Basic materials companies around the globe were worried about potential slowdown in China, and now it looks like those stocks have risen," Alan Lancz, president of Alan B. Lancz & Associates Inc., an investment advisory firm in Toledo, Ohio.

Thursday's U.S. data supported an upbeat view of the economy, however. Initial claims for state unemployment benefits in the latest week dropped a surprising 16,000 to a seasonally adjusted 339,000 versus expectations for 351,000.

The Dow Jones industrial average <.dji> was up 78.16 points, or 0.53 percent, at 14,754.46. The Standard & Poor's 500 Index <.spx> was up 11.02 points, or 0.70 percent, at 1,589.81. The Nasdaq Composite Index <.ixic> was up 28.70 points, or 0.88 percent, at 3,298.35.

United Parcel Service Inc , considered an economic bellwether, advanced 2 percent to $85.14 after the world's largest package-delivery company reported a quarterly profit above analysts' estimates.

Akamai Technologies Inc surged 19.1 percent to $43 as the best performer on the S&P 500 after the Internet content delivery company posted first-quarter earnings above Wall Street estimates late on Wednesday and also forecast second-quarter results above analysts' expectations.

But Exxon Mobil Corp and 3M Co bucked the trend as their shares fell.

Exxon fell 1.1 percent to $88.48. The largest U.S. company by market capitalization said its quarterly profit edged up, helped by its chemicals business, but oil and gas production fell.

Fellow Dow component 3M Co lost 2.4 percent to $105.29 after the diversified U.S. manufacturer posted first-quarter earnings and revenue that missed Wall Street expectations and cut its 2013 profit forecast.

(This version of the story corrects paragraph 7 to remove extra word "to" before "a surprising 16,000" to read "dropped a surprising 16,000".)

(Editing by Bernadette Baum and Kenneth Barry)

Source: http://news.yahoo.com/stock-index-futures-signal-slightly-higher-open-081750934--finance.html

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Tsarnaev questioned for 16 hours before he was read rights

Dzhokhar Tsarnaev (FBI handout)Dzhokhar Tsarnaev, suspected of bombing the Boston Marathon with his older brother, Tamerlan Tsarnaev, was questioned for 16 hours by authorities before being read his Miranda rights, the AP reports today.

Tsarnaev, a 19-year-old college student, confessed his role in the crime during the questioning in his hospital room, but that confession may not be admissible in court. Once he was advised of his right to seek counsel and remain silent by a representative from the U.S. attorney's office, the suspect stopped talking.

Police are allowed to question suspects without first Mirandizing them, but then their statements are not admissible in court. If police ask questions that seek to uncover future threats to the public, something called the "public safety exception" provides a loophole to this rule.

So in Tsarnaev's case, if they had asked him if he knew of any planned attacks, or whether there were any bombs planted around Boston, his answers would theoretically be OK to use in a case against him. Authorities questioned both the Christmas Day "underwear bomber" Umar Farouk Abdulmutallab?for 50 minutes?and the attempted Times Square bomber Faisal Shahzad without first reading them their Miranda rights using the public safety exception.

Some Republicans, led by Sen. Lindsey Graham of South Carolina, have argued that Tsarnaev should be treated as an enemy combatant and detained indefinitely so he can be questioned without a lawyer. Since Tsarnaev is a U.S. citizen arrested on U.S. soil?and because authorities have not connected him to a larger terror network?holding him as an enemy combatant most likely would be illegal.

Even if Tsarnaev's reported confession is not allowed to be used in the courtroom, authorities told the AP that the Tsarnaevs told a witness?a man whose car they carjacked?that they were responsible for the bombing. Law enforcement has also uncovered physical evidence from the scene that they think ties the Tsarnaevs to the bombings.

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Source: http://news.yahoo.com/blogs/lookout/tsarnaev-questioned-16-hours-read-miranda-rights-135531333.html

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US options exchange reopens after half-day outage

NEW YORK (AP) ? Trading on the biggest exchange for financial options resumed Thursday following an outage caused by software problems.

The Chicago Board Options Exchange reopened at 12:50 p.m. Eastern time after being closed from the start of the trading day. The shutdown forced traders to scramble for alternatives.

The outage followed a brief scare in financial markets Tuesday afternoon when hackers sent a false Associated Press tweet reporting explosions at the White House. Stocks plunged for two minutes as computerized trading systems unloaded stocks. Regulators are increasingly looking into the safety of computerized trading systems.

Initially, there was speculation that CBOE computers had been hacked, but exchange officials believe hackers were not involved, said CBOE spokesperson Gail Osten. She said it was a "software issue" that had stopped the exchange from opening.

The CBOE is the largest U.S. options exchange. It is the only place to trade two popular options ? one a bet on the future price of the Standard and Poor's 500 stock index, the other a kind of insurance against wild stock-price swings.

Options give the holder the right, but not the obligation, to buy and sell stocks or other financial assets in the future.

The exchange normally opens at 9:30 a.m. When it opened at 12:50 p.m., the only trading was in options on the S&P 500, according to a CBOE Twitter feed. Trading of other options resumed ten minutes later, the CBOE tweet said.

Some traders shrugged off the outage.

"I don't think it is too big of a deal if it's a one day thing. If it keeps happening, of course, that's different," said Ryan Detrick, a senior technical strategist at Schaeffer's Investment Research.

The volatility index traded on the CBOE ? known as the VIX ? is a measure of how likely stocks will swing in the future. Last week, investors anxious over the Boston Marathon bombings and slowing economic growth in China sent the VIX up 40 percent to 17.6 at one point. But the option quickly fell back to 13, around where it's been trading since the start of 2013.

The VIX was at 13.3 at 2:45 p.m. on Thursday.

Jay Tigay, a VIX trader at Stutland Equities, described VIX trading as a sort of neglected stepchild in the flow of business news. So he was glad the CBOE was getting relatively big play on business news channel CNBC during the shutdown ? though "not the attention they want."

Stock of the CBOE Holdings, the parent company of the exchange, didn't seem hurt by the shutdown, though. It was up 28 cent, or nearly 1 percent, to $36.73 as of 2:45 p.m.

Source: http://news.yahoo.com/us-options-exchange-reopens-half-day-outage-195109989--finance.html

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Thursday, April 25, 2013

Syrian troops capture key town near Damascus

BEIRUT (AP) ? After five weeks of battle, Syrian government troops captured a strategic town near Damascus, cutting an arms route for rebels trying to topple President Bashar Assad's regime, state media and activists said Thursday.

By taking the town of Otaybah, east of the capital, the army has dealt a major setback to opposition forces, who in the past months have made gains near the city they eventually hope to storm.

With fresh supplies of weapons from foreign backers, the rebels have recently seized military bases and towns south of the capital in the strategically important region between Damascus and the border with Jordan, about 160 kilometers (100 miles) away.

The regime has largely kept the rebels at bay in Damascus, although opposition fighters control several suburbs of the capital from which they have threatened the heart of the city, the seat of Assad's power. Last month government troops launched a massive campaign to repel the rebel advances near the capital, deploying elite army units to the rebellious Damascus suburbs and pounding rebel positions with airstrikes.

The director of the Syrian Observatory for Human Rights, Rami Abdul-Rahman, said government troops regained control of Otaybah late Wednesday.

State-run SANA news agency said Thursday that the army has "restored complete control" over Otaybah. The official news services also said Assad's troops "discovered a number of tunnels which were used by terrorists to move and transfer weapons and ammunitions."

The regime and state media refer to rebels as terrorists and accuse them of being part of a foreign plot seeking to destroy Syria.

"It's a huge victory for the regime, and a big blow to the opposition that is now in danger of losing other towns and villages around Damascus," Abdul-Rahman said of the army's campaign.

On Thursday, the army was already capitalizing on the territorial gains, pounding southern suburbs of Damascus including the long-contested Daraya with artillery and air strikes, according to the Observatory. The group relies on a network of activists on the ground that also reported fierce clashes between rebels and army troops to the east of the capital.

The army's offensive to dislodge rebel fighters from neighborhoods ringing Damascus is part of the government's broader campaign to secure central provinces of Hama and Homs, and areas along the Lebanese border. The region is of strategic value to Assad's regime because it links Damascus with the coastal enclave that is the heartland of Syria's Alawites and also home to the country's two main seaports, Latakia and Tartus.

Syria's regime is dominated by the president's minority Alawite sect ? an offshoot of Shiite Islam ? while the rebels are mostly from the country's Sunni majority. Assad's major allies, the Lebanese militant Hezbollah group and Iran, are both Shiite.

Otaybah is located on a road linking Damascus to its international airport, along which rebels have been transporting weapons and other supplies from neighboring Jordan. The capital's surrounding towns and neighborhoods have been opposition strongholds during the 2-year-old conflict.

Losing control of the town will make the defense of rebel enclaves in southern suburbs such as Douma, Harasta and others very difficult, Abdul-Rahman said. The loss of the arms supply route is a major blow to opposition forces trying to overthrow Assad.

The Syrian conflict started with largely peaceful protests against Assad's regime in March 2011 but eventually turned into a civil war.

The fighting has exacted a huge toll on the country, killing more than 70,000 people, laying waste to cities, towns and villages and forcing more than a million people to flee their homes and seek refuge abroad. Millions have also been displaced inside Syria.

International aid agencies have been pleading for funds to help refugees in neighboring countries such as Jordan and Lebanon. They have also been asking the Syrian government to allow aid convoys into the country and facilitate access to the area inside cities and towns that have been affected by fighting.

The latest damage to the country's rich cultural heritage came on Wednesday, when the minaret of the landmark 12th century Umayyad Mosque in the northern city of Aleppo was destroyed during fighting in the old walled city.

Source: http://news.yahoo.com/syrian-troops-capture-key-town-near-damascus-064600068.html

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Wednesday, April 24, 2013

Humans Evolved Flexible, Lopsided Brains

The two halves of the human brain are not symmetrical. This lopsidedness, which arises during brain development, may be a stamp of the adaptability of the human brain, a new study suggests.

Researchers compared geometric differences between brain scans of humans and chimpanzees. They observed structural asymmetries in both human and chimpanzee brains, but human brains were especially asymmetric. The findings, published online today (April 23) in the journal Proceedings of the Royal Society B, suggest human and chimp brains evolved a high degree of flexibility during development.

The human brain is known to be asymmetric ? the "left brain" is involved in language processing, for example, while the "right brain" is where spatial reasoning takes place. "It's very common that there are some areas that are bigger in the left hemisphere than in the right hemisphere," said lead study author Aida G?mez-Robles, an anthropologist at The George Washington University in Washington, D.C. [10 Things You Didn't Know About the Brain]

Asymmetry and specialization of the brain's hemispheres were once thought be distinctly human traits, but primates and other animals possess them as well. The asymmetries take several forms: A population may have brains with one half that is consistently larger than the other, known as directional asymmetry; a population may consist of some individuals with one brain half larger and some with the other half larger, known as anti-symmetry; or a population can exhibit differences in both halves that differ from the average shape, known as fluctuating asymmetry.

Genetics is thought to play a role in the first two asymmetries. But scientists believe fluctuating asymmetry, in which individuals in a population possess a variety of differences in brain shape, may result when environmental factors affect the brain's development.

In their study, G?mez-Robles and her colleagues compared the differences between live human brains and chimpanzee brains using magnetic resonance imaging (MRI) scans. They processed the scans to obtain a 3D reconstruction of just the brain hemispheres. Then they used statistical techniques to map and compare the brain structures between individual humans and chimpanzees, as well as between the two species.

Both human and chimpanzee brains had asymmetries that varied across each population, the analysis showed. Compared with the chimpanzee brain, human brains showed even more variation in structure size between individuals in the population.

Overall, human brains had enlarged frontal and parietal lobes compared with chimp brains, as expected. Generally, chimps had relatively short and broad brain proportions, whereas humans had long and narrower proportions.

The pattern of brain variation seen in both humans and chimpanzees suggests this structural variation evolved in a common ancestor, enabling them to adapt to selective pressures in their environment.

The lack of symmetry in the brains of both animals, but especially humans, may be a sign of the flexibility, or plasticity, of their brains. "We know that plasticity is an important trait in the function of the brain," which is critical for human cognitive evolution, G?mez-Robles said. Being flexible allows the brain to adapt to the conditions of its environment, and this adaptation results in less symmetric brains. ?

It would be interesting to compare the results with the brains of other primates besides humans and chimpanzees, G?mez-Robles said, but this would require having skull MRIs (brain images) from those animals.

Follow Tanya Lewis on Twitter?and Google+.?Follow us @livescience, Facebook?& Google+. Original article on?LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/humans-evolved-flexible-lopsided-brains-230719380.html

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FocusTwist app for iOS gives you Lytro-esque refocusable images

Focus Twist for iPhone gives you Lytosesque selective focus

Arqball has just released the FocusTwist app for iOS that lets you selectively focus after taking an image -- without investing $400 in a Lytro light field camera. It works by automatically taking several shots with different focus points from your iPhone's camera, delivering the best results if you hold very still and have subjects in the near foreground and far background. You can then change focus by clicking different parts of the resulting image, which is hosted on the company's server and can be shared via a link. After playing with the app ourselves for a bit (see the More Coverage link), we've got to admit we're stupidly hooked -- you can grab it at the source for $1.99.

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Through Dirt-Cheap Genetic Testing, Counsyl Is Pioneering A New Bioinformatics Wave

Jen Baumgartel opted for in-vitro fertilization after learning for a Counsyl test that she and her husband were carriers for the severest form of Smith-Lemli-Opitz syndrome.For cynics who say that Silicon Valley has become too mired in photo-sharing apps and addictive games, take a 15-minute drive to South San Francisco. In a non-descript lab is a company that may be paving the way for the Valley’s next wave of disruptive startups, which marry software with data from the human genome. Counsyl is doing genetic tests that look for more than 400 mutations and at least 100 genetic disorders for parents who are planning children. At $599 total, or $99 with insurance, their tests cost a fraction of standard ones, which often only look for a single condition like cystic fibrosis, and run anywhere from $100 to $500. A full panel of tests for Ashkenazi Jews, a minority famously at risk for various genetic conditions, can run about $4,000 to $5,000 from companies like Quest Diagnostics. Founded six years ago, Counsyl has grown to handle carrier screening for 2.5 percent of all births in the U.S. To ramp up, Counsyl has quietly taken in roughly $65 million in funding from firms like Founders Fund, Felicis Ventures, India’s Manipal Group, Google’s senior vice president of corporate development David Drummond, WTI, Rosemont Seneca, and Google research scientist Jeff Dean. “We want to make the genome practically useful,” said CEO Ramji Srinivasan. “People don’t necessarily care about genomics. At some point, the novelty of this data will wear off. The diagnostic utility has to be extremely obvious: can it change someone’s behavior? Can it make them make a different decision?” The company is coming of age at a time when the costs of full-genome sequencing are falling faster than even Moore’s Law would have predicted. Full genome sequencing — not the kind of testing where you’re handling only select snippets of DNA — runs at around $8,000 now, down from $100 million in 2001. Capitalizing on this, Counsyl has products for both snippet tests and a more comprehensive test that is about $999 for 10,000 genetic mutations. It’s helped women like?Jen?Baumgartel, a nurse in a Nashville, Tennessee in vitro fertilization clinic, choose IVF over conceiving naturally. Through a Counsyl test, she found out both her and her husband were carriers for Smith-Lemli-Opitz syndrome, which put their potential children at risk of heart problems, developmental delays and cleft palate. They had a one-in-four chance of passing the condition on, and both Baumgartel and her husband carried the genes for the

Source: http://feedproxy.google.com/~r/Techcrunch/~3/0txAiQvd_1E/

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Battling with bugs to prevent antibiotic resistance

Apr. 23, 2013 ? New scientific research published today in the journal PLoS Biology shows that bacteria can evolve resistance more quickly when stronger antibiotics are used.

Researchers from the University of Exeter and Kiel University in Germany treated E. coli with different combinations of antibiotics in laboratory experiments.

Unexpectedly they found that the rate of evolution of antibiotic resistance speeds up when potent treatments are given because resistant bacterial cells flourish most during the most aggressive therapies.

This happens because too potent a treatment eliminates the non-resistant cells, creating a lack of competition that allows resistant bacteria to multiply quickly. Those cells go on to create copies of resistance genes that help them rapidly reduce the effectiveness of the drugs. In tests this effect could even cause E.coli to grow fastest in the most aggressive antibiotic treatments.

In addition to evolution experiments, the results of this Engineering and Physical Sciences Research Council (EPSRC) and Medical Research Council (MRC) funded research were confirmed using mathematical models and whole-genome sequencing of resistant and non-resistant E. coli.

Professor Robert Beardmore, EPSRC Research Fellow from the University of Exeter said: "We were surprised by how quickly the bacteria evolved resistance. We nearly stopped the experiments because we didn't think some of the treatments should be losing potency that fast, sometimes within a day. But we now know that the bacteria remaining after the initial treatment have duplicated specific areas of their genome containing large numbers of resistance genes. These gene copies appear more quickly when the antibiotics are combined, resulting in the rapid evolution of very resistant bacteria.

"Designing new treatments to prevent antibiotic resistance is not easy, as this research shows, and governments may need to increase their funding for antibiotics research if scientists are to be able to keep pace with the rapid evolution of bacterial pathogens that cause disease."

Dr Rafael Pena-Miller from Biosciences at the University of Exeter said: "The evidence that combining antibiotics to make a more potent therapy can lead to the creation of more copies of the genes the bacteria needs to be resistant is of real concern."

Professor Hinrich Schulenberg from Kiel University in Germany said: "The interesting thing is that the bacteria don't just make copies of the genes they need. Just in case, they copy other genes as well, increasing resistance to antibiotics the cells weren't even treated with."

About 440 000 new cases of drug-resistant tuberculosis emerge annually, causing around 150 000 deaths. Statistics like this recently lead the Department of Health to state that antibiotic resistance poses one of the greatest threats to human health.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/zprA_T5Qf9w/130423172704.htm

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Scientists map all possible drug-like chemical compounds: Library of millions of small, carbon-based molecules chemists might synthesize

Apr. 22, 2013 ? Drug developers may have a new tool to search for more effective medications and new materials.

It's a computer algorithm that can model and catalogue the entire set of lightweight, carbon-containing molecules that chemists could feasibly create in a lab.

The small-molecule universe has more than 10^60 (that's 1 with 60 zeroes after it) chemical structures. Duke chemist David Beratan said that many of the world's problems have molecular solutions in this chemical space, whether it???s a cure for disease or a new material to capture sunlight.

But, he said, "The small-molecule universe is astronomical in size. When we search it for new molecular solutions, we are lost. We don't know which way to look."

To give synthetic chemists better directions in their molecular search, Beratan and his colleagues -- Duke chemist Weitao Yang, postdoctoral associates Aaron Virshup and Julia Contreras-Garcia, and University of Pittsburgh chemist Peter Wipf -- designed a new computer algorithm to map the small-molecule universe.

The map, developed with a National Institutes of Health P50 Center grant, tells scientists where the unexplored regions of the chemical space are and how to build structures to get there. A paper describing the algorithm and map appeared online in April in the Journal of the American Chemical Society.

The map helps chemists because they do not yet have the tools, time or money to synthesize all 10^60 compounds in the small-molecule universe. Synthetic chemists can only make a few hundred or a few thousand molecules at a time, so they have to carefully choose which compounds to build, Beratan said.

The scientists already have a digital library describing about a billion molecules found in the small-molecule universe, and they have synthesized about 100 million compounds over the course of human history, Beratan said. But these molecules are similar in structure and come from the same regions of the small-molecule universe.

It's the unexplored regions that could hold molecular solutions to some of the world's most vexing challenges, Beratan said.

To add diversity and explore new regions to the chemical space, Aaron Virshup developed a computer algorithm that built a virtual library of 9 million molecules with compounds representing every region of the small-molecule universe.

"The idea was to start with a simple molecule and make random changes, so you add a carbon, change a double bond to a single bond, add a nitrogen. By doing that over and over again, you can get to any molecule you can think of," Virshup said.

He programed the new algorithm to make small, random chemical changes to the structure of benzene and then to catalogue the new molecules it created based on where they fit into the map of the small-molecule universe. The challenge, Virshup said, came in identifying which new chemical compounds chemists could actually create in a lab.

Virshup sent his early drafts of the algorithm's newly constructed molecules to synthetic chemists who scribbled on them in red ink to show whether they were synthetically unstable or unrealistic. He then turned the criticisms into rules the algorithm had to follow so it would not make those types of compounds again.

"The rules kept us from getting lost in the chemical space," he said.

After ten iterations, the algorithm finally produced 9 million synthesizable molecules representing every region of the small-molecule universe, and it produced a map showing the regions of the chemical space where scientists have not yet synthesized any compounds.

"With the map, we can tell chemists, if you can synthesize a new molecule in this region of space, you have made a new type of compound," Virshup said. "It's an intellectual property issue. If you're in the blank spaces on our small molecule map, you're guaranteed to make something that isn't patented yet," he said.

The team has made the source code for the algorithm available online. The researchers said they hope scientists will use it to immediately start mining the unexplored regions of the small molecule universe for new chemical compounds.

The research was supported by a grant from the National Institutes of Health (P50-GM067082).

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Journal Reference:

  1. Aaron M Virshup, Julia Contreras-Garc?a, Peter Wipf, Weitao Yang, David N. Beratan. Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds.. Journal of the American Chemical Society, 2013; : 130402114828001 DOI: 10.1021/ja401184g

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/59XGfriSyDc/130422154945.htm

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Tuesday, April 23, 2013

Ultra Mobile debuts $19 calling plan with unlimited international SMS

Ultra Mobile debuts $19 calling plan with unlimited international SMS

If you're living on a tight budget but still need to keep in touch with loved ones who live abroad, you'll be glad to know of a new calling plan from Ultra Mobile. The upstart MVNO offers discounted access to T-Mobile's network, and for $19 per month, you'll fetch unlimited text messages to 194 countries, 250 voice minutes (with $1.25 toward international calling), and 50MB of data usage. For comparison, Simple Mobile offers a $25 plan that includes unlimited international texting and domestic calling, but if you let your thumbs do most of the talking, Ultra Mobile brings a lot of value to the table. You can snag its $19 plan starting tomorrow, which might be the perfect match for whatever Nokia has up its sleeve.

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Source: http://www.engadget.com/2013/04/22/ultra-mobile-19-dollar-plan/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Sunday, April 21, 2013

Automakers target Chinese buyers at Shanghai show

Buick Riviera Concept 2013 model is unveiled ahead of the Shanghai International Automobile Industry Exhibition (AUTO Shanghai) in Shanghai, China Friday, April 19, 2013. (AP Photo/Eugene Hoshiko)

Buick Riviera Concept 2013 model is unveiled ahead of the Shanghai International Automobile Industry Exhibition (AUTO Shanghai) in Shanghai, China Friday, April 19, 2013. (AP Photo/Eugene Hoshiko)

Buick Riviera Concept 2013 model is unveiled ahead of the Shanghai International Automobile Industry Exhibition (AUTO Shanghai) in Shanghai, China Friday, April 19, 2013. (AP Photo/Eugene Hoshiko)

Geely Holding Group Vice President Feng Qingfeng unveils the Chinese automaker's new electric car "EC7" during a press conference ahead of the Shanghai International Automobile Industry Exhibition (AUTO Shanghai) in Shanghai, China Friday, April 19, 2013. (AP Photo/Eugene Hoshiko)

Dieter Zetsche, chairman of Daimler AG, unveils Mercedes-Benz new concept car "GLA" during a press conference ahead of the Shanghai International Automobile Industry Exhibition (AUTO Shanghai) in Shanghai, China Friday, April 19, 2013. (AP Photo/Eugene Hoshiko)

(AP) ? Ford, Fiat and other automakers that are competing for a share of China's huge but crowded market are showcasing their latest sedans, SUVs and sports cars at the country's biggest auto show.

Ford Motor Co. showed off its newest Mondeo sedan on Saturday and a sport version of its smaller Focus aimed at China's coveted urban buyers. Italy's Fiat debuted a Viaggio sedan that it said was its first model created for China.

China's auto market is the world's biggest and total sales rose 13 percent last year. But competition is intensifying as sales growth slows and global automakers that see China as a key part of their future spend heavily to create models for local tastes.

GM China president Bob Socia said China is a "very, very competitive market."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-19-China-Auto%20Show/id-8e1e5e44704241f9bb833a479687e480

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Sell Your Stuff and Get Some Extra Cash This Weekend

Whether you're hard up for cash or just want to de-crapify your home, selling your stuff online can be awesome. You get rid of stuff you don't need, and you get some extra pocket money in return. Here are some tips for getting the most money back.

Prepare Your Stuff For Sale

S

As you gather up your clutter, you probably need to do a little work on it before you sell it off. A little work can go a long way to getting you more money?especially if you're selling old gadgets. If you've got a smartphone, make sure you've protected it from wear and are selling it at the right time. If you're selling a laptop, give it a little makeover?it's probably become pretty dirty and worn out over the years. And no matter what you do, wipe your data?both on your computer and your phone?before you hand it off to a stranger. Check out our guide to selling your gadgets online for more preparation tips, while you're at it.

Where to Sell Based on Your Needs

Before you rush off to eBay or Craigslist, think about what you're selling and what you want from your sale. Certain places are better than others, depending on your needs. For example, if you're selling electronics, books, or video games, Amazon and eBay are great choices, but they won't be if you're selling clothing. Check out our complete guide to selling your unwanted crap for an idea of where to sell.

If you're looking for something a little more hassle-free, consider Amazon's Fulfillment program, or even Facebook. Heck, you could even set up your own little online store without too much effort, giving you complete control over the whole process. For more ideas, check out our Hive Five poll on the five best places to set up shop online. You're bound to find the perfect place with a bit of research.

Create Your Listings

When it comes time to actually put your stuff up for sale, don't be careless. A little effort goes a long way. Take good photos to ensure they attract attention, find out how much your items are worth by searching for completed sales (or using a site like WorthMonkey), and set your eBay auctions to end at the optimal time for the most bidders. Bundling products together will get you a quicker sale, but not necessarily a better one. Patience is key with selling online: if you wait long enough, someone will offer you a great price. You don't need to take the first offer that comes your way unless you're really desperate to unload the object in question.

Lastly, as you're waiting for that sale, make sure you don't succumb to the loads of scams and lowballers out there. Check out our tips to avoid getting screwed on Craigslist (and elsewhere online) to make sure someone doesn't take advantage.

That's a lot of links to throw at you at once, but there are a lot of great tricks out there to help you get the most for your money. Luckily, we have a checklist that'll help you keep track of it all. Click here to check it out, and good luck!

Have a great weekend!

Images by quazie, Leremy (Shutterstock), and Kevin Dooley.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/3HYbOm-A5OY/sell-your-stuff-and-get-some-extra-cash-this-weekend-476431930

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Official: FBI interviewed older suspect in 2011 (The Arizona Republic)

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Arkansas turns to different lethal injection drug

LITTLE ROCK, Ark. (AP) ? After surrendering its supply of a lethal injection drug to federal agents in 2011, Arkansas turned to a somewhat surprising place to look for another drug: a list from lawyers for several death row inmates.

The state Department of Correction told The Associated Press this week that it decided to use phenobarbital after attorneys for several death row inmates mentioned in a lawsuit that it might be an available drug. Phenobarbital, which is used to treat seizures, has never been used in a U.S. execution, and critics contend that a drug that's untested in lethal injections could lead to inhumane deaths for condemned prisoners.

"People should not be using inmates as an experiment," said David Lubarsky, who chairs the anesthesiology department at the University of Miami's medical school. "And that is basically what this is. It's basically experimenting."

As drugmakers object to their products' use in lethal injections, more death penalty states have been looking at different options. But the states have revealed little, if any, information about how they go about picking drugs.

"It's been: Here's what we're going to do and unless you can prove it's excruciatingly painful, the courts, they're not experts either, they're going to allow it go forward," said Richard Dieter, executive director of the Washington-based Death Penalty Information Center.

Just last year, Missouri announced plans to use propofol, the anesthetic blamed for pop star Michael Jackson's death, even though that drug hadn't been used in a lethal injection. In explaining the change, the state merely said the decision was due to a lack of another drug. Department of Corrections spokeswoman Mandi Steele declined to comment further Friday, saying the state's execution protocol is the subject of legal action.

The changes came after states' supplies of sodium thiopental dried up when the makers put it off-limits for use in executions. Oklahoma was the first to try pentobarbital, a sedative commonly used to euthanize animals, leading some other states to follow suit. But now those supplies are running out after manufacturers banned its use by states for executions.

In Arkansas, Department of Correction spokeswoman Shea Wilson said the agency consulted medical sources before picking phenobarbital, but Wilson refused to say what those sources were. She also wouldn't say whether the agency considered using other drugs.

"Our research indicated the drug would take effect within 5 minutes and should result in a painless death," Wilson said in an email to the AP.

But even the paperwork that came with the state's supply of phenobarbital, which is a kind of drug known as a barbiturate, warns that the "toxic dose of barbiturates varies considerably," according to records the AP obtained.

"We have no idea about whether or not the injection of such large doses will produce some acute tolerance effect, in which case you may or may not actually be able to kill someone with it," Lubarsky said.

However, Mike Ritze, a family physician and Republican state lawmaker in Oklahoma said phenobarbital is humane.

"I don't want to compare humans with veterinarians, but for years, they euthanized animals and you can use anything in the barbiturates and they're all very humane. Basically, the person just closes their eyes," said Ritze, a proponent of the death penalty who said he has used phenobarbital to treat patients with seizures.

Arkansas and many of the nation's more than 30 other death penalty states once used a virtually identical three-drug process: The barbiturate sodium thiopental was administered to put the inmate to sleep, and two other drugs were administered to stop breathing and the heart.

As sodium thiopental supplies dried up, Arkansas and several other states initially turned their attention overseas, obtaining the drug from a British supplier. But in 2011, they lost their supplies to federal agents amid legal questions about how they got the drug.

No one responded to phone messages left Friday at West-Ward Pharmaceuticals, the company that Arkansas bought its latest batch of drugs from.

Lubarsky, the anesthesiology department chair, said that "just because the drug sounds alike ? thiopental, pentobarbital, phenobarbital ? that doesn't mean they're that close a cousin."

Those three drugs vary in the amount of time it takes for them to start kicking in. Sodium thiopental is like a light switch: It starts working quickly, and it wears off quickly. Phenobarbital, the drug Arkansas plans to use, takes a bit longer to kick in, and it takes longer for the drug to wear off.

Some say that means executions using phenobarbital could take more time.

Federal public defender Jenniffer Horan wrote to Arkansas Democratic Gov. Mike Beebe this week, calling on the governor to review the state's planned use of phenobarbital, saying it carries a "substantial risk of a lingering and inhumane death." A spokesman for Beebe said the governor's office is reviewing the letter in conjunction with the attorney general's office.

Arkansas hasn't executed an inmate since 2005 and it doesn't have any executions scheduled, though 37 inmates are on death row. Should executions be set, the state plans to inject inmates with the anti-anxiety drug lorazepam before giving them a large dose of phenobarbital.

"The lorazepam is a pre-execution sedative, but it also is intended to offset the side effects of the barbiturate should any develop," Wilson said in an email.

However, Jon Groner, a surgery professor at the Ohio State University College of Medicine, says that might not work because lorazepam can make some people excitable, instead of relaxed. Groner has worked with lawyers who represent death row inmates and has written about how lethal injections create an ethical conflict he calls the Hippocratic paradox.

Medical professionals are arguably the most knowledgeable when it comes to the drugs used in lethal injections, but they're supposed to heal people, not harm them.

"These states are not experts in pharmacology," Dieter said. "They're just trying to carry out their law."

___

Associated Press writers Andrew Welsh-Huggins in Columbus, Ohio, and Jim Salter in St. Louis contributed to this report.

___

Follow Jeannie Nuss at http://twitter.com/jeannienuss

Source: http://news.yahoo.com/arkansas-turns-different-lethal-injection-drug-214639034.html

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